2019: Articles in Press
Review Article

The Antacid Efficacy of Maalox in Comparison to a Range of Antacids

Dettmar PW
Technostics Limited, Daisy Building, Castle Hill Hospital, Cottingham, East Yorkshire, HU16 5JQ, UK
Strugala V
Technostics Limited, Daisy Building, Castle Hill Hospital, Cottingham, East Yorkshire, HU16 5JQ, UK
Fisher J
Technostics Limited, Daisy Building, Castle Hill Hospital, Cottingham, East Yorkshire, HU16 5JQ, UK
Woodcock AD
Technostics Limited, Daisy Building, Castle Hill Hospital, Cottingham, East Yorkshire, HU16 5JQ, UK
Published July 10, 2019
Keywords
  • Antacid,
  • Maalox,
  • Neutralization,
  • Onset of action,
  • Duration of action,
  • Efficacy,
  • Drug interactions,
  • Side effects
  • ...More
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Abstract

This review has comprehensively reviewed the literature relating to the use of antacids in the treatment of the symptoms of heartburn, regurgitation and indigestion and the findings of gastro-esophageal reflux (GER) including defining the onset and duration of action of some key antacids available in the global market place. The rate and duration of neutralization was determined using a modified Rossett and Rice test. The review also investigated the frequency of use of antacids, common antacid drug interactions, common antacid side effects and the efficacy of antacids in daily use.  As well as the efficacy of antacids on the symptoms, endoscopic findings and gastric pH in clinical studies.
Antacids are cheap, easily available, over the counter (OTC) remedies that target mild symptoms of heartburn and indigestion associated with GER.  They should be inexpensive, safe and palatable for use in the self-medication /OTC market place. They are widely used and in 2017 antacid sales were reported to be worth $10 billion worldwide.   The ideal antacid needs to be efficacious with a rapid onset of action in neutralising stomach contents and a long duration of action maintaining a prolonged reduction in stomach acidity preferably in both the fasted and full stomach in an acidic and a weak acidic environment. 
The review particularly investigated the efficacy of Maalox Tablet products and Maalox Suspension products to compare the products in terms of onset of action to neutralise stomach contents and the duration of neutralization.