Vol. 4 No. 1 (2021): Articles in Press
Case Report

Salivary Duct Carcinoma with Neuroendocrine Differentiation: Report of a Confusing Case Arising in the Parotid Gland

Harada H
Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine

Published 2021-02-23


  • Salivary duct carcinoma,
  • High-grade carcinoma,
  • Neuroendocrine differentiation,
  • Parotid gland,
  • Large cell neuroendocrine carcinoma


We here report an extremely rare case of salivary duct carcinoma with neuroendocrine differentiation. The patient was a 60-year-old Japanese male who presented with facial palsy that had persisted for two months and was referred to a local university hospital. Open biopsy resulted in a diagnosis of parotid carcinoma and radical parotidectomy and cervical dissection were performed. Histopathological examination revealed a tumor consisting of irregular, large and small invasive nests with numerous luminal structures that, in the larger solid nests, were often accompanied by comedo necrosis. Intraductal growth was seen surrounding the tumor. Immunohistochemically, the tumor cells were positive for androgen receptor along with AE1/AE3, CAM5.2, 34betaE12, and CK7. There were also reactions for synaptophysin and CD56, but not for chromogranin A. The histopathological features of, and diagnostic problems related to, neuroendocrine carcinoma are discussed.