2019: Article in press
Review Article

Plasmapheresis in Ophthalmology

Voinov VA
Aphaeresis Therapy Department of the I.P. Pavlov First State Medical University of Saint-Petersburg, Russia
Karchevscy KS
Aphaeresis Therapy Department of the I.P. Pavlov First State Medical University of Saint-Petersburg, Russia
Isaulov OV
Aphaeresis Therapy Department of the I.P. Pavlov First State Medical University of Saint-Petersburg, Russia
Published April 23, 2019
Keywords
  • Blindness,
  • Diabetic retinopathy,
  • Optical neuropathy,
  • Autoantibodies,
  • Toxic metabolites,
  • Macular degeneration
  • ...More
    Less

Abstract

Loss of sight is one of the most severe disabling factors in human. The total number of such people is known to account for millions worldwide. In North America alone more than 1 million are completely blind and about 14 million have some degree of sight loss. There are many different diseases that lead to sight loss such as diabetic retinopathy, senile macular degeneration, various types of autoimmune retinopathy, optic nerves damage and many others. As a rule, they cannot be corrected with glasses, and not always amenable to drug therapy. Often the cause of these diseases is accumulation of various autoantibodies and other metabolites, the molecules large size of which does not allow them to be excreted by the kidneys and the fact of their accumulation indicates impossibility of their removal with help of drug therapy. It makes us resort to such method of their direct removal from the body as plasmapheresis and the aim of this study is to justify its use in ophthalmology.